Pyrazine-derived disulfide-reducing agent for chemical biology.
نویسندگان
چکیده
For fifty years, dithiothreitol (DTT) has been the preferred reagent for the reduction of disulfide bonds in proteins and other biomolecules. Herein we report on the synthesis and characterization of 2,3-bis(mercaptomethyl)pyrazine (BMMP), a readily accessible disulfide-reducing agent with reactivity under biological conditions that is markedly superior to DTT and other known reagents.
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ورودعنوان ژورنال:
- Chemical communications
دوره 50 67 شماره
صفحات -
تاریخ انتشار 2014